Diagnosis: Xeroderma Pigmentosum
Pathology: An inherited defect in the DNA repair mechanisms of the skin. In practical terms, this causes an \'allergy\' to sunlight, resulting in severe cracking, blistering, and burns after relatively minimal sun exposure. The inability to repair the damage caused by UV rays causes an enormous cumulative lifetime risk in developing all manners of skin cancer (estimated at a risk >10,000 times higher than the healthy population). The disease was first described in 1870 by Moritz Kaposi (first to describe Kaposi\'s Sarcoma, a skin cancer) as \'parchment skin\'.
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